منابع مشابه
Wst 49.11-12 B17 Corr
The mathematical modeling of spatial biofilm formation that provides the capability to predict biofilm structure from first principles has been in development for the past six years. However, a direct and quantitative link between model predictions and the experimentally observed structure formation still remains to be established. This work assesses the capability of a state-of-the-art techniq...
متن کاملFragments of the Bacterial Toxin Microcin B17 as Gyrase Poisons
Fluoroquinolones are very important drugs in the clinical antibacterial arsenal; their success is principally due to their mode of action: the stabilisation of a gyrase-DNA intermediate (the cleavage complex), which triggers a chain of events leading to cell death. Microcin B17 (MccB17) is a modified peptide bacterial toxin that acts by a similar mode of action, but is unfortunately unsuitable ...
متن کاملAll-boron analogues of aromatic hydrocarbons: B17- and B18-.
We have investigated the structural and electronic properties of the B(17)(-) and B(18)(-) clusters using photoelectron spectroscopy (PES) and ab initio calculations. The adiabatic electron detachment energies of B(17)(-) and B(18)(-) are measured to be 4.23 ± 0.02 and 3.53 ± 0.05 eV, respectively. Calculated electron detachment energies are compared with experimental data, confirming the prese...
متن کاملIn vitro characterization of DNA gyrase inhibition by microcin B17 analogs with altered bisheterocyclic sites.
Microcin B17 (MccB17) is a 3.1-kDa Escherichia coli antibiotic that contains thiazole and oxazole heterocycles in a peptide backbone. MccB17 inhibits its cellular target, DNA gyrase, by trapping the enzyme in a complex that is covalently bound to double-strand cleaved DNA, in a manner similar to the well-known quinolone drugs. The identification of gyrase as the target of MccB17 provides an opp...
متن کاملIs Cancer Merely A Vitamin Deficiency Disease? Vitamin B17 Laetrile Cancer Treatment Now Available in Australia
Despite his punishing workload at the clinic, Dr Tait has also managed to erect a very impressive web site, which provides more data on Vitamin B17 than any other web site I have seen. His site is well worth a visit by anyone who has ever wondered why the American FDA and Australian Government have responded to B17 with such vicious disregard for human life. A link to Dr Tait’s Fountain of Life...
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ژورنال
عنوان ژورنال: Arthropod Management Tests
سال: 2012
ISSN: 2155-9856
DOI: 10.4182/amt.2012.b17